ethylene glycol msds science lab

Please enable it to take advantage of the complete set of features! Whitehouse Station, NJ: Merck & Co; 2006. Product name: Ethylene glycol CBnumber: CB7852707 CAS: 107-21-1 EINECS Number: 203-473-3 Synonyms: ethylene glycol,Monoethylene Glycol diarrhea. Federal government websites often end in .gov or .mil. Industry Circular No. Bogdanich, W.; McLean, R. "Poisoned Toothpaste in Panama Is Believed to Be From China". <> 1 Reagent Lane [glucose divided by 18] /Filter /FlateDecode 1.2. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Ingestion: Note that many hospitals must send these samples to a reference laboratory, and results are not usually available in time to guide initial clinical management. 8600 Rockville Pike Estimated ethylene glycol level = OG 6.2. [13] It appears diethylene glycol may be more hazardous to humans[14] than implied by oral toxicity data in laboratory animals.[2]. Uses It can be a contaminant in consumer The primary results revealed that the mixture was more effective than using salt alone. 2001-2023 The Pain Reliever Corporation. Once DEG reaches the liver, it is metabolized by enzymes. Panama awaits the extradition of Criado for her hearing. sharing sensitive information, make sure youre on a federal If you are frustrated on your journey back to wellness - don't give up - there is hope. However, they advised that the syrups suspected of causing the deaths in Gambia, were not sold locally in Indonesia.[77][78][79]. Wang was caught and Qiquihar was shut down by the authorities. [30] The next year, an Austrian electric power plant (sterreichische Draukraftwerke) in Carinthia announced that technicians developed a way to produce energy through burning 30 million liters of contaminated wine. MeSH 2004). Possible birth defect hazard. The storage moduli of samples prepared with a 1:1 ratio of glycerol to EG, FITC-BSA adsorption on the PEG hydrogels prepared with different ratios of glycerol to EG. WebMesoporous carbon catalyst produces H2O2, and titanium silicalite-1 catalyst would subsequently oxidize ethylene into ethylene glycol with the in-situ generated H2O2. the reaction of the glycine metabolite with benzoic acid, which forms hippuric acid. Inhalation: Bookshelf 4 0 obj It is also used in the manufacture of polyethylene terephthalate (PET) and in oil and gas processing. Misiak P, Markiewicz KH, Szymczuk D, Wilczewska AZ. WebProduct Name Ethylene Glycol Monobutyl Ether (Laboratory) Cat No. Causes respiratory tract Vos records revealed the syrup had been bought from Sinochem International Chemicals Company through a German trader, Metall-Chemie. liver and kidney damage. [2][7], The symptoms of poisoning typically occur in three characteristic intervals:[2], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[2]. Depending on the conditions, varying amounts of DEG and related glycols are produced. 2018 Jul 4;13:3921-3935. doi: 10.2147/IJN.S165210. WebThe glycol scale used is based upon the relationship between concentration and RI for two component mixtures of ethylene of propylene in water. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. : BP230-1; BP230-4 CAS-No 107-21-1 Synonyms Monoethylene glycol; 1,2-Ethanediol Recommended Use Laboratory chemicals. It is odorless, but has a sweet taste. 5 ppm TWA; Skin - potential significant contribution to overall exposure by the cutaneous r oute. WebClear, colorless liquid. [57][58] Days later, Colgate-Palmolive found counterfeit toothpaste with its name, which was contaminated with DEG and found at dollar-type discount stores in New York, New Jersey, Pennsylvania and Maryland. WebETHYLENE - C 2H 4 MSDS (Document # 001022) PAGE 1 OF 9 MATERIAL SAFETY DATA SHEET Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards All hazard information pertinent to this gas has been provided in this Material Safety Data Sheet, per the requirements of the OSHA Hazard Communication Standard (29 CFR Identification Product Name Ethylene glycol Cat No. V rugm ncercai mai trziu. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. WebEthylene glycol is a synthetic liquid substance that absorbs water. However, potentially toxic serum concentrations of ethylene glycol (2030 mg/dL) do not always produce early symptoms in children or adults. << The factory of the medication manufacturer, Pharval, was subsequently investigated by Dr. Joel Selanikio (also of CDC, and an Epidemic Intelligence Service classmate of Katherine O'Brien). Webunchanged ethylene glycol by the kidneys. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. }YLif*)FOrvE>udX(uV82Y0Yz}yV:+4`\eg_1iLA 0YQDn?7 7?I950?1sRtQ`?H"\L}qEC3+kyVj,dfD* Rd@|o}KE/Rn'r,z0j3],82QYy wFQqy3*}4r~R!KY.ThxG) L] *INLLLYh=9nTj["2,,ATt'U{k`bT > Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by "FDA Advises Consumers to Avoid Toothpaste From China Containing Harmful Chemical. Some blood gas analyzers might mistake elevated serum glycolic acid as elevated lactic acid, leading to a false positive lactic acid result (Marwick et al. Product Technical Specification: Specifications of Disodium EDTA O'Neil M. The Merck Index. Authorities warn against using some toothpastes, Taste of Raspberries, Taste of Death The 1937 Elixir Sulfanilamide Incident, "Wallace Reveals How Federal Agents Traced Elixir to Halt Fatalities", "Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination", "Popular Wines found to hold toxic chemical. May cause central nervous system depression. The industry generally operates to maximize MEG production. Absence of urinary crystals, however, does not rule out poisoning. [71] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. [4], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. The site is secure. Aspiration may lead They also arrested 12 people in connection with the incident. peroxidizable. The product was recalled and after an investigation, the Drug Controller General of India, VG Somani, said at India Pharma 2020, that the GMP was not followed, and negligence was found during the production process itself. [4], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. 2016 Aug;40:172-181. doi: 10.1016/j.actbio.2016.04.045. Seventeen other persons have also been charged related to this incident. May cause reproductive and fetal Language links are at the top of the page across from the title. May Doctors had no idea what was happening: the mysterious illness was attacking elderly citizens with hypertension and diabetes history. Skin: WebEDTA - Ethylene Diamine TetraAcetic Acid is a transparent water soluble belonging to a class of chelators that bind-chelate-metals. amounts may cause CNS depression. Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review. The Himachal Pradesh government is filing a criminal case against the company and its executives.[75][76]. Chronic inhalation and ingestion may cause effects similar to those % The fluorescence spectroscopy images further demonstrated that the tbFGF conjugated micelles could specifically bind to the tumor cells that over-expressed FGFRs and then release rhodamine B into the cytoplasm. MFk t,:.FW8c1L&9aX: rbl1 Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. [6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[42]. InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, InChI=1/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, Except where otherwise noted, data are given for materials in their, 1937 The Massengill incident (United States). WebThe chemical compound 1,2-dichloroethane, commonly known as ethylene dichloride (EDC), is a chlorinated hydrocarbon.It is a colourless liquid with a chloroform-like odour.The most common use of 1,2-dichloroethane is in the production of vinyl chloride, which is used to make polyvinyl chloride (PVC) pipes, furniture and automobile upholstery, wall ", "Scandal over poisoned wine embitters village in Austria.". The children later developed kidney failure and died. This is because aldehyde dehydrogenase (ADH) has a higher affinity for ethanol than for ethylene glycol. eCollection 2018. WebES COMPLEAT EG CONCENTRATE (ETHYLENE GLYCOL BASED ANTIFREEZE) MSDS No. The preparation of PEG hydrogels was realized by adding glycerol as a crosslinker, and the physical and the mechanical properties were easily controlled by changing the crosslinker concentration as well as the PEG chain length. 3 0 obj to pulmonary edema. with different mole fractions, where the evapn. The point is, use caution when interpreting the osmolal gap. Warning! [2] DEG is a widely used solvent. During the month of July 1985, Austrian wines were found to contain up to 1,000 parts per million of DEG, giving them a desirable sweetness. Ethylene Glycol Monostearate 111-60-4 30-50 * Ethylene Glycol 107-21-1 1-10 * *The exact percentage (concentration) of composition has been withheld as a trade secret. Protein diffusion characteristics in the hydrogels of poly(ethylene glycol) and zwitterionic poly(sulfobetaine methacrylate) (pSBMA). 1 0 obj Communication with the laboratory is critical in poisoning cases for several reasons: All patients with known or suspected ethylene glycol ingestion require the following tests: A blood or serum ethanol level will establish whether ethanol is contributing to the initial CNS symptoms. % This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. WebBrowse the latest lab supplies and equipment for all your science lab essentials. x=]s@=LV`JW_5WG"tN75_Ous~=?w^,6lV}8`?? WebEthylene glycol is primarily used as a component of de-icer and anti-icer/anti-freeze fluid used in aircraft de-icing and anti-icing operations, and as an anti-freeze component in motor vehicles. endobj WebEthylene glycol. Urine from an exposed person might fluoresce under a Woods lamp because some antifreeze products contain fluorescein. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. [53][54][55] For the end of the month, the Chinese government committed to investigate the "supposedly" tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. p*o!vZ;32K] TgRPF} + [BAT (ethanol) divided by 4.6 (if present)]. It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. WebAn ethylene glycol level (in mg/dL) might be estimated from the osmolal gap (OG) if it is the only osmotically active poison present and levels are taken early in the course. Bethesda, MD 20894, Web Policies The LD50 for small mammals has been tested at between 2 and 25g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans (in high concentration only). They identified Tianhong Fine Chemicals Factory as the manufacturer. and transmitted securely. J Control Release. Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Int J Nanomedicine. Recent reviews have argued that using the osmolal gap as a screening tool for ethylene glycol has significant limitations and remains hypothetical (Glaser 1996; Koga et al. the precipitation of calcium by the oxalic acid metabolite of ethylene glycol, and. The presence of ethanol delays the metabolism of ethylene glycol to its acidic metabolites. The tbFGF could recognize fibroblast growth factor receptors (FGFR) that are highly expressed by a variety of human cancer cells. This being the second incident involving counterfeit glycerine, it prompted the Nigerian National Agency for Food And Drug Administration and Control (NAFDAC) to adopt zero tolerance for counterfeits. Tracked Poisoned Drugs, but Trail Went Cold in China", "From China to Panama, a trail of Poisoned Medicine", "Aumentan Envenenados con Dietilene Glycol", "Outbreak of acute renal failure in Panama in 2006: a case-control study", "Caso dietilene glycol puede viciarse: Troitio", "24 Nios afectados por utilizacin de txico", "Rasfer Internacional se declara en bancarrota", "Panam bloquea el proceso espaol por el caso del jarabe asesino", "Testing of Glycerin for Diethylene Glycol", "China investigating toothpaste containing potentially deadly chemical", "U.S. checking all toothpaste imports from China", "7online.com: Toothpaste recall expands 6/18/07", "The Everyman Who Exposed Tainted Toothpaste", "Nigeria child deaths from tainted teething mixture rise to 84", "84 Children Are Killed by Medicine in Nigeria", "NAFDAC Negotiates State of the art Anti Counterfeiting Equipment", "Laudo da Polcia Civil aponta que cerveja adulterada causou doena misteriosa em BH", "Polcia confirma 3 morte por sndrome nefroneural", "Ministrio da Agricultura identifica contaminao em oito rtulos de cervejas da Backer", "Morre 10 vtima por intoxicao de cerveja da Backer", "Behind killer cough syrup Coldbest: Glaring gaps in regulation and its manufacture", "J&K children deaths: Kids consumed cough syrup with poisonous chemical, probe reveals", "Contaminated Indian medicines linked to deaths of 66 children in Gambia: WHO", "Gambia says child deaths linked to cough syrup have risen to 70", "Indonesia bans all syrup medicines after death of 99 children", https://en.wikipedia.org/w/index.php?title=Diethylene_glycol&oldid=1144917005, Articles with dead external links from July 2019, Articles with permanently dead external links, Articles with dead external links from March 2023, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, 244 to 245C (471 to 473F; 517 to 518K), This page was last edited on 16 March 2023, at 08:14.